MicroRNAs and its Dysregulation in Cancer Progression

Abstract

MicroRNAs (miRNAs) are small, conserved, non-coding RNA plays important role in inpost-transcriptional gene regulation. Recent studies have elucidated the function of dysregulatedmiRNA in plethora of diseases commonly in human cancer. Various mechanisms, by which miRNA gets dysregulated include: abnormal transcription of miRNA, dysregulation in miRNA biogenesis, genomic aberrations and dysregulated epigenetic modification. Aberrantly expressed miRNA has been studied to affect the 
hallmark of cancer. Recent studies have highlighted on the potential of miRNA to act as therapeutic target and biomarker. In this review paper, we focused on the biogenesis, regulation of miRNA along with the dysregulation of it in human cancer and some other diseases, along with it highlighting miRNA roles in therapy.