Evaluation of Uric acid, Creatinine, BMI, EGFR in hypothyroid patients and euthyroid controls

Abstract

Introduction
Hypothyroidism is a clinical syndrome resulting from deficiency of thyroid hormone leading to
generalised slowing down of metabolic process. The thyroid gland, located anterior to the
trachea between the cricoid cartilage and the suprasternal notch, plays a pivotal role in
maintaining thermogenic and metabolic homeostasis in adults by producing thyroxine (T4) and triiodothyronine (T3) hormones. Hypothyroidism is associated with reduced Glomerular
Filtration Rate (GFR), increased serum creatinine, and alterations in water excretion.
Haemodynamic changes in hypothyroidism contribute to elevated serum creatinine levels.