Background: Iron is an essential trace element. It has a pivotal role in maintaining various cellular functions and enzyme reactions; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. Objectives: The aim of this study was to investigate the role of the serum iron, serum ferritin and total iron binding capacity (TIBC) in the causation of coronary artery disease (CAD) and their relationship with other risk factors of CAD. Material and Methods: The study group consisted of 40 angiographically confirmed cases of CAD and 40 healthy controls. Serum lipids, serum lipoproteins, serum iron and TIBC were estimated by autoanalyzer (Dxc 900 Beckman coulter). Serum ferritin was measured on Mini VIDAS and malondialdehyde (MDA) was being done by Thiobarbituric acid method. Results: Significant difference was found among the controls and CAD patients regarding the occurrence of weight, height, BMI, Hip circumference and Waist circumference and FBS. The ratio of Total cholesterol and HDL was significantly raised in CAD patients (4.80) than controls (3.48). Serum iron and Serum ferritin levels were significantly elevated in patients with CAD when compared with control groups (118.2 ± 22.7mg/dl versus 105 ± 19.6mg/dl, p<0.001) and (218.3 ± 58.6mg/dl versus 139.8 ± 66 mg/ dl, p<0.0001) respectively. TIBC levels were lower in patients than controls (211.5 + 61.2 versus 309.8 + 79.2, p<0.0001). When body iron was compared with other risk factors (like smoking, hypertension, diabetes mellitus, tobacco etc) of the disease it was found to be significantly raised. Conclusion: Study concluded that increased levels of serum iron, ferritin might consider as risk factor for CAD in conjunction with other risk factors.