Background: Heart Failure (HF) is one of the commonest formforms of cardiovascular disease, which is defined pathologically by inability of the heart to perform its routine function i.e. to get filled and pump out blood to the other parts of he body. The prevalence of HF is continuously increasing globally. In the Swedish Natural Diabetes Registry, it was found that the incidence of HF increased linearly with increase in glycosylated Hemoglobin (HbA1C). The present study was undertaken with the pursuit of studying the effectiveness of Heart Failure Reversal Therapy/HFRT on VO2 peak, HbA1c, Systolic Blood Pressure (SBP), diastolic BP (BP), BMI and dependency on conventional medicines. Material and Methods: The present study was observational one, conducted at Madhavbaug clinics all over Maharashtra, India. Total duration of the study was two years from May 2016 to April 2018 and included patients of HF with HbA1c > 6.5. HFRT was given for minimum 7 settings over a period of 90 days (±15 days). All the parameters mentioned above were measured again at day 90 and finding were compared with baseline. Results: 33 patients completed HFRT and were included for analysis. VO2 peak showed significant improvement from 16.91±5.94 at baseline to 29.81±6.57 at day 90 (p<0.0005). HbA1c reduced from 8.34±1.53 at baseline to 6.77±1.56 at day 90 (p<0.0005), BMI from 27.90±3.2 to 25.68±2.94 (p<0.0005), SBP from 132.52±17.33 mmHg at baseline to 123.94 at day 90 (p<0.01) and DBP from 81.16±9.62 at baseline to 76±7.47 mm Hg at day 90 (p<0.01). Conclusion: The study findings showed significant improvement in all vital parameters of HF and diabetes i.e. VO2max, BMI, SBP, DBP which is anticipated to have a positive impact on the patient’s health status.