Objective: Coronary artery disease (CAD) causes more than 1 million deaths in China annually. The incidence of coronary artery disease tends to increase in the middle age and elderly people. Pulse pressure is associated with increased risk of CAD in middle-aged and older subjects, whereas soluble receptor for advanced glycation end products (sRAGE) and S100A12 are involved in pathology of atherosclerosis. In this study, we examine the associations of the expression level of sRAGE, S100A12 and PP value in both CAD and non-CAD groups; thus, providing more comprehensive strategies on preventing CAD. Method: Selected were divided into two main groups based on their angiograph results: CAD group (patients with at least one coronary artery of more than 50% occlusion) and Non-CAD Group (patients with less than 50% occlusion or without coronary artery occlusion). Soluble RAGE (sRAGE) and S100A12 concentration in blood samples were collected before CAG procedure were measured using ELISA. Pulse Pressure was measure from the difference between SBP and DBP. Results: Significant decrease in concentration of serum sRAGE (p<0.05) and S100A12 (p<0.01) was observed, while PP value (p<0.01) had significantly higher level in patients with CAD. The value of PP (r = 0.35, p < 0.01), expression level of both sRAGE (r = -0.21, p< 0.01) and S100A12 (r = -0.24, p < 0.01) had association with prevalence of CAD. Conclusion: Low level of sRAGE expression and higher pulse pressure in CAD group are associated to coronary artery disease within middle age and elderly people of the Chinese population. Therefore providing alternative novel therapeutic strategies may prevent CAD before entering the middle age.