Background: Myocardial infarction (MI) is a multifactorial and polygenic cardiovascular disease with high mortality rate. Early diagnosis could help in precautionary measures and change in life style. Many studies used dermatoglyphics as noninvasive technique to predict the incidence of genetic diseases. Here, we tried to assess the association of dermatoglyphic pattern between MI and controls. Methods: We investigated dermatoglyphic patterns among 800 participants (n=400 MI cases and n=400 control groups) representing South Indian population. Patients with MI were compared with control groups who did not have any history of MI. Results: Showed higher frequency whorls in MI patients and loops in control group (p<0.001). The study showed significant difference in distribution of whorl (OR = 0.298, 95%CI=0.223- 0.399, p=0.0001), loop (OR = 3.537, 95%CI=2.639-4.741, p=0.0001), arch (OR = 0.545, 95%CI=0.405-0.733, p=0.0001). Further, mean values of A-B ridge count (OR = 1.421, 95%CI=1.167-1.731, P=0.0001) of MI and control groups were significant (p<0.05). Conclusion: The present study showed that there is an association between dermatoglyphic patterns and MI cases. Further, findings suggest that dermatoglyphic patterns may contribute to etiology of early prediction of MI.