Background: No study has been undertaken on people of Asian Indian origin to investigate the age and sex variation in the prevalence of cardiovascular disease (CVD) risk factors. Objectives: To investigate the age and sex variation in the prevalence of CVD risk factors among the people of Asian Indian origin. Materials and Methods: A total of 682 (302 males and 380 females) participants aged 25–85 years took part in the study. The subjects were categorized into 4 groups, namely, Group I (25–34 years), Group II (35–44 years), Group III (45–54 years), and Group IV (55 years and above). Height, weight, and the circumferences of minimum waist (MWC) and maximum hip were collected using standard techniques. Waist–hip ratio (WHR) was then calculated. Percentage of body fat (%BF) and body mass index (BMI) were measured using an Omron body fat analyzer. Left arm systolic (SBP) and diastolic (DBP) blood pressure were taken from each participant with the help of an Omron MI digital electronic blood/pulse monitor. Metabolic pro les, namely, total cholesterol (TC), triglyceride (TG), high (HDL), low (LDL), very low-density lipoprotein (VLDL), and fasting blood glucose (FBG) were also measured using an autoanalyzer. Results: One-way analysis of variance revealed signi cant differences for age, BMI, MWC, WHR, SBP, DBP, TC, TG, LDL, VLDL, and TC:HDL and TG:HDL ratios across the groups. It was observed that there were signi cant sex-speci c group differences (male [2 (12)] =29.22, P < 0.01 and female [2 (12)] =56.69, P < 0.001) for obesity, high BP, high TC, high TG, and high FBG. But no signi cant group-speci c sex difference was evident for either of the risk factors, except for Group IV. Conclusion: Age irrespective of sex modulates CVD risk factors and warranted prevention as early as middle age.