CLINICAL OUTCOME AFTER TYMPANOPLASTY WITH USE OFAUTOLOGUS PLATELET RICH PLASMA IN CASE OF TYMPANIC MEMBRANE PERFORATION: A ONE-YEAR OBSERVATIONAL STUDY

Abstract

In order to evaluate the efficacy of autologous platelet rich plasma in myringoplasty patients with respect to graft uptake and hearing improvement. In order to evaluate the graft uptake and hearing improvement postoperatively, a prospective study was conducted from 2021 to 2022 in the Department of Otorhinolaryngology, Integral Institute of Medical Sciences & Research. The study involved 80 patients, 40 of whom had myringoplasty with autologous PRP usage (Group A) and 40 of whom had myringoplasty alone (Group B). Group A demonstrated graft uptake on postoperative day 21 in 92.5% of the 40 patients who had myringoplasty with autologous platelet rich plasma, but Group B demonstrated only 25% graft uptake. The results showed statistical significance (p 0.0001). (2) There were a very small number of reperforations in Group B, while 95% of Group A exhibited no residual or reperforation at all.(3) The mean A-B gap improvement for group A was 17.37 (SEM of 0.62) and for group B it was 16.75 (not statistically significant).(4) Our research found an infection rate of 2.5% in group A and 7.5% in group B, although there was no statistically significant difference between the two.