A Cross sectional Study on Association of Human Papilloma Virus Infection in Cervical Malignancy: Record based Regression Analysis

Abstract

Papilloma viruses are small, non-enveloped, epitheliotropic, double stranded deoxyribonucleic acid (DNA) viruses that infect mucosal and cutaneous epithelia in a wide variety of higher vertebrates in a species-specific manner and induce cellular proliferation. The study was conducted to observe the association & prevalence of Human Papilloma Virus (HPV) infection in suspected (pre-malignant lesion) and known cases of cervical malignancy and to study the risk factor of HPV infection. Study design is based on observational recordbased hospital study via cross-sectional survey and review, and conclusion was drawn on primary data collection and analysis. Patients (Women) coming to out-patient department (OPD) and emergency department of Obstetrics and Gynecology at Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India from March 2018 to February 2019 with cervical growth and unhealthy Cervix with abnormal uterine bleeding (AUB) or history of
contact bleeding were considered as population. Sample size of 177 patients were considered for this study. Written and informed consent was obtained from all the participants after brief explanation of the procedure. Menstrual and obstetric history was taken in relation to the presenting complaints and then these patients were examined. Observational parameters
recorded from each patient were age, socio-demography, age at first intercourse, age at first childbirth, reproductive history, marital history, tobacco consumption, type of cancer, type of HPV and clinical staging. It was found that association of HPV with unhealthy cervix which were either diagnosed as cancer or premalignant lesion (low grade squamous intraepithelial lesion or high grade squamous intraepithelial lesion) was found to be 94%. In the study, prevalence of HPV was found high in women in mid age group, women belonging to low socio-economic strata, women who were married at young age and women with high parity