TO STUDY THE THYROID DYSFUNCTION IN PATIENTS ATTENDING A TERTIARY CARE CENTRE

Abstract

Introduction: Thyroid dysfunction is characterised as an abnormal serum thyroid stimulation hormone (TSH) level in conjunction with normal or altered thyroid hormones (triiodothyronine-T3 and thyroxine-T4). Overt hyperthyroidism is defined as a drop in circulating blood TSH levels along with an increase in circulating T3 and T4, whereas subclinical hyperthyroidism is defined as a decrease in circulating blood TSH levels together with normal circulating T3 and T4 levels. Overt hypothyroidism is defined as an increase in circulating blood TSH with decreased circulating T3 and T4, whereas subclinical hypothyroidism is defined as an increase in circulating blood TSH with normal circulating T3 and T4. Aim and Objective: To Study the Thyroid Dysfunction in Patients Attending a Tertiary Care
Centre. Material and Methods: This was a hospital-based study conducted at G.C.R.G Institute of Medical Sciences in Lucknow. This study included 550 respondents, with 390 (71%) being female and 160 (29%) being male. The participants' thyroid condition was classified as euthyroidism, overt hyperthyroidism, subclinical hyperthyroidism, overt hypothyroidism, or subclinical hypothyroidism
based on thyroid function test results. Total hypothyroidism consists of overt hypothyroidism as well as subclinical hypothyroidism, whereas total hyperthyroidism consists of overt hyperthyroidism and subclinical hyperthyroidism. Overnight fasting venous blood was obtained from the hospital patients. Thyroid function test panel (T3, T4 and TSH) were assayed by the Cobas e411 immunoassay analyzer and its test kits. Results: The current study found that the prevalence of thyroid dysfunction, specifically hypothyroidism and subclinical hypothyroidism, was higher in this region, although the cause of the ailment remains unknown. Furthermore, the condition was prevalent among women and persons of all ages. Conclusion: The study identifies the prevalence of thyroid dysfunction in this area and might serve as a baseline for future research.