Clinico-epidemiological study of PMLE and biochemical correlation of thyroid dysfunction

Abstract

Polymorphic light eruption (PMLE) is a prevalent photodermatosis characterized by pruritic papules or plaques that develop after exposure to sunlight. It predominantly affects young females, especially during spring and summer. The precise etiology remains unclear, but immune dysregulation, particularly related to UV-induced damage, is believed to play a key role. Thyroid dysfunction, particularly hypothyroidism, has been associated with immune alterations that may impact skin sensitivity and exacerbate PMLE. This study aims to explore the clinico-epidemiological profile of PMLE and its biochemical correlation with thyroid dysfunction