DEVELOPMENT OF DILTIAZEM-LOADED INTERPENETRATING CROSS LINKED MICROSPHERES FOR CONTROLLED DRUG DELIVERY: A COMPREHENSIVE REVIEW ON ALOE VERA GEL, DILTIAZEM HCL, AND SODIUM ALGINATE-BASED SYSTEMS

Authors

  • Sandeep Kumar,Mr. Akhilesh Kumar Author

DOI:

https://doi.org/10.48047/

Keywords:

Diltiazem HCl, interpenetrating polymer network, microspheres, sodium alginate, Aloe vera gel, controlled release, cross-linking, hydrogel, cardiovascular drug delivery

Abstract

Diltiazem hydrochloride (DH) is a widely prescribed non-dihydropyridine calcium channel blocker indicated for the management of hypertension, chronic stable angina, and supraventricular arrhythmias. Despite its clinical efficacy, the conventional immediate-release  formulation necessitates administration three to four times daily due to its short plasma elimination

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Published

2025-12-20

Issue

Vol. 16 No. 12 (2025): Volume 16 Issue 12 (2025)

Section

Articles