CEFTRIAXONE BLOCKS THE POLYMERIZATION OF Α‑SYNUCLEIN AND EXERTS NEUROPROTECTIVE EFFECTS IN VITRO

Authors

  • ANCHURI NAGARAJU Author

DOI:

https://doi.org/10.48047/

Keywords:

Ceftriaxone, α-synuclein, Parkinson’s disease, circular dichroism, 6- OHDA, PC12 cells.

Abstract

The β-lactam antibiotic ceftriaxone was suggested as a therapeutic agent in several neurodegenerative disorders, either for its ability to counteract glutamate-mediated toxicity, as in cerebral ischemia, or for its ability to enhance the degradation of misfolded proteins, as in Alexander’s disease. Recently, the efficacy of ceftriaxone in neuroprotection of dopaminergic
neurons in a rat model of Parkinson’s disease was documented. 

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Published

2020-12-05

Issue

Vol. 11 No. 11 (2020): volume 11 issue 11 (2020)

Section

Articles