Published on:December 2016
    Journal of Cardiovascular Disease Research, 2016; 7(4):152-154
    Case Report | doi:10.5530/jcdr.2016.4.5

    Retroperitoneal Bleed with Ticagrelor Administration Following Fibrinolytic Therapy in Acute ST-Elevation Myocardial Infarction


    Venkatesh Tekur Krishnamurthy

    Department of Cardiology, Apollo hospitals 154/11, Opp IIM-B, Bannerghatta Road Bangalore 560076 India.


    ST-elevation myocardial infarction, in anticipation of primary percutaneous coronary intervention, clopidogrel, prasugrel or ticagrelor are given with Aspirin on presentation. The Authors report a case of acute ST elevation anterior wall myocardial infarction administered ticagrelor with Asprin with intent to treat by primary percutaneous coronary intervention, but patient subsequently opted for intravenous fibrinolytic therapy instead of primary percutaneous coronary intervention . Although fibrinolytic therapy was successful in achieving reperfusion, patient developed significant retroperitoneal bleed requiring multiple blood transfusions. Only clopidogrel is recommended in the setting of fibrinolytic therapy in the guidelines and no data are presently available with ticagrelor.

    Key words: ST elevation myocardial infarction, Ticagrelor, Fibrinolysis, Primary percutaneous coronary intervention (PCI).

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