Background: The etiology of the ventricular dilation and dysfunction that occurs in idiopathic dilated cardiomyopathy (DCM) is unknown. Aim: The present study was aimed to study clinical characteristics of the patients admitted with idiopathic DCM and compare them with healthy controls. Methods: Thirty newly diagnosed patients with DCM and 30 healthy control were enrolled from Cardiology OPD, PGIMER, Chandigarh from Jan 2011 to Jun 2012. Patients with heart failure secondary to idiopathic DCM of age >18 years were included if they were willing, provide written informed consent and does not meet any of the exclusion criteria. Idiopathic DCM was diagnosed by the presence of left ventricular dilatation and systolic dysfunction (LVEF<40%) on echocardiography in the absence of coronary artery disease, hypertension or valvular disease. Results: Mean age of idiopathic DCM patients and control was 48.37 ± 10.82 years and 49.2 ± 9.27 (P=0.75) respectively. There were more males (66.7%) than females (33.3%) in the patient group. It was observed that the treatment with beta blockers, furosemide, spironolactone, ACE inhibitors, and ARBs significantly improved ejection fraction (EF) (P=0.000), and LVES (P=0.000). Conclusion: In our study, treatment with the medications significantly improved EF and LVES. However, there was no treatment-based difference in the patients on ACE inhibitors or ARBs in the improvement in EF. Our study also observed significance difference in platelets count, SGOT, SGPT, and LDL levels in idiopathic DCM patients when compared with healthy controls.