E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Article 


Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK.

Abstract
Introduction: Cardiovascular disease is the leading cause of mortality and morbidity all over the world. Among these
cardiovascular deaths, half result from coronary artery disease (CAD). Increased prevalence of CAD is associated with
increased levels of inflammatory markers. Phenotypic variations of these markers may depend on physiological stress
or genetic variations. Materials and Methods: Single nucleotide polymorphism analysis of methylenetetrahydrofolate
reductase (MTHFR), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1) genes was done by PCR-DNA
sequencing method. Results: Statistically significant elevation of inflammatory markers- homocysteine, hsCRP and
fibrinogen were found in CAD group (pā‰¤0.05). Multiple sequence alignment showed a single nucleotide mutation i.e.,
c.677 C>T (p. A222V) in exon-4 of MTHFR in 10% of CAD group and was associated with an increased risk of CAD (OR:
12.21). Mutations observed in exon-4 of IL-6 gene (in 26% of cases) was significantly associated with an increased risk
of CAD (OR: 36.36). ICAM-1 (exon-6) mutation i.e., c.1405 A>G (p. K469E) was observed in 18% of patients and an
increased risk of CAD (OR: 23.12). Conclusion: Polymorphisms observed in MTHFR, IL-6 and ICAM-1 genes in South-
Indian ethnic population which are associated with elevated levels of inflammatory markers – homocysteine, hsCRP and
fibrinogen appear to be predisposing factors for atherosclerosis.

Key words: Coronary artery disease, Methylenetetrahydrofolate reductase, Interleukin-6, Intercellular adhesion molecule-1, Homocysteine, hsCRP, Polymorphism, South-India.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Latheef K
Articles by Rajasekhar D
Articles by Vanajakshamma V
Articles by Aparna BR
Articles by Chaudhury A
Articles by Sarma PVGK
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK. Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study. J Cardiovasc. Dis. Res.. 2018; 9(3): 115-122. doi:10.5530/jcdr.2018.3.27


Web Style

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK. Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study. http://www.jcdronline.org/?mno=93748 [Access: January 18, 2022]. doi:10.5530/jcdr.2018.3.27


AMA (American Medical Association) Style

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK. Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study. J Cardiovasc. Dis. Res.. 2018; 9(3): 115-122. doi:10.5530/jcdr.2018.3.27



Vancouver/ICMJE Style

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK. Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study. J Cardiovasc. Dis. Res.. (2018), [cited January 18, 2022]; 9(3): 115-122. doi:10.5530/jcdr.2018.3.27



Harvard Style

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK (2018) Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study. J Cardiovasc. Dis. Res., 9 (3), 115-122. doi:10.5530/jcdr.2018.3.27



Turabian Style

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK. 2018. Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study. Journal of Cardiovascular Disease Research, 9 (3), 115-122. doi:10.5530/jcdr.2018.3.27



Chicago Style

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK. "Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study." Journal of Cardiovascular Disease Research 9 (2018), 115-122. doi:10.5530/jcdr.2018.3.27



MLA (The Modern Language Association) Style

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK. "Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study." Journal of Cardiovascular Disease Research 9.3 (2018), 115-122. Print. doi:10.5530/jcdr.2018.3.27



APA (American Psychological Association) Style

Latheef K, Rajasekhar D, Vanajakshamma V, Aparna BR, Chaudhury A, Sarma PVGK (2018) Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study. Journal of Cardiovascular Disease Research, 9 (3), 115-122. doi:10.5530/jcdr.2018.3.27





Most Viewed Articles
  • Effects of right ventricular septal versus apical pacing on plasma natriuretic peptide levels
    nikoo M.H, ghaedian m. m., kafi M., fakhrpour A., Jorat M. V., Pakfetrat M., Ostovan M., Zahra Emkanjoo
    J Cardiovasc. Dis. Res.. 2011; 2(2): 104-109
    » Abstract » doi: 10.4103/0975-3583.83036

  • Massive pericardial effusion as the only manifestation of primary hypothyroidism
    Radheshyam Purkait , Anand Prasad , Ramchandra Bhadra , Arindam Basu
    J Cardiovasc. Dis. Res.. 2013; 4(4): 248-250
    » Abstract » doi: 10.1016/j.jcdr.2014.01.001

  • Impact of light exercises in selective cognitive response andhandballshooting accuracy performance in Mesopotamia handball players
    Ahuda Naji Zaidan, Qusay Mohammed Hamdan, Mohammed Kadhim Saleh, Samer Saadoun Abd El , Rida
    J Cardiovasc. Dis. Res.. 2021; 12(2): 141-145
    » Abstract » doi: 10.31838/jcdr.2021.12.02.18

  • Reduced nitrate level in individuals with hypertension and diabetes
    Shiekh Gazalla Ayub, Taha Ayub, Saquib Naveed Khan, Rubiya Dar, Khurshid Iqbal Andrabi
    J Cardiovasc. Dis. Res.. 2011; 2(3): 172-176
    » Abstract » doi: 10.4103/0975-3583.85264

  • Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians
    Mithun Das, Susil Pal, Arnab Ghosh
    J Cardiovasc. Dis. Res.. 2010; 1(2): 86-91
    » Abstract » doi: 10.4103/0975-3583.64442

  • Most Downloaded
  • Assessment of the Knowledge and Attitude of Male Students towards Smoking Based on Health Belief Model
    Rafat Rezapour-Nasrabad, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Khatereh Rostami, Amin Kiani, Afsaneh Ghasemi
    J Cardiovasc. Dis. Res.. 2020; 11(4): 116-121
    » Abstract » doi: 10.31838/jcdr.2020.11.04.20

  • Diabetic Retinopathy, The Automated of Detection of Retinal Fundus Images with Probabilistic Neural Networks (PNN)
    Elvina Amanda, Marischa Elveny, Rahmad Syah
    J Cardiovasc. Dis. Res.. 2020; 11(4): 302-306
    » Abstract » doi: 10.31838/jcdr.2020.11.04.54

  • Investigation of the Relationship between Social Support and Adherence to Treatment among Elderly Individuals with Type II Diabetes Mellitus
    Afsaneh Ghasemi, Rafat Rezapour-Nasrabad, Leila Nikrouz, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Zahra Khiali
    J Cardiovasc. Dis. Res.. 2020; 11(4): 122-129
    » Abstract » doi: 10.31838/jcdr.2020.11.04.21

  • Evaluation of the RV function in ASD patients pre and post transcatheter occlusion by speckle tracking
    Ghazi Farhan Haji, Venus Abdulwahid Alwan, Sa`ad Hashim Mohammed
    J Cardiovasc. Dis. Res.. 2020; 11(1): 24-30
    » Abstract » doi: 10.31838/jcdr.2020.11.01.07

  • Preclinical Study of Derivative of 3-Oxypiridone in Experimental Pre-Eclampsia
    Alesya V. Yurakova, Sofya Y.Skachilova, Lyudmila M.Danilenko, Indira S. Kochkarova, Natalia V.Ekimova, Anastasia V. Gureeva, Il'ya S. Rozhkov, Adelaida V. Polyanskaya
    J Cardiovasc. Dis. Res.. 2020; 11(4): 66-70
    » Abstract » doi: 10.31838/jcdr.2020.11.04.11

  • Most Cited Articles
  • Alterations in oropharyngeal airway volume and dimensions following treatment with mandibular anterior repositioning in class II malocclusion
    Dr Wagisha Barbi, Dr. Jasmine Nindra, Dr. Pranav Manek, Dr. Partho Shankar Chakraborty, Dr. Priyadarshini Rangari
    J Cardiovasc. Dis. Res.. 2021; 12(6): 603-607
    » Abstract & References » doi: 10.31838/jcdr.2021.12.06.81
    Cited : 6 times [Click to see citing articles]

  • The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children
    Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra
    J Cardiovasc. Dis. Res.. 2021; 12(6): 484-489
    » Abstract & References » doi: 10.31838/jcdr.2021.12.06.65
    Cited : 5 times [Click to see citing articles]

  • To Determine the Influence of Body Mass Index on Blood Pressure in People with Hypertension
    Dr. Rajesh Kumar Pandey, Asha Kumari, Dr.S.N.Sachit, Dr.V.K.Mishra
    J Cardiovasc. Dis. Res.. 2021; 12(4): 1634-1643
    » Abstract & References » doi: 10.31838/jcdr.2021.12.03.172
    Cited : 4 times [Click to see citing articles]

  • IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA
    Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur
    J Cardiovasc. Dis. Res.. 2021; 12(3): 2882-2895
    » Abstract & References » doi: 10.31838/jcdr.2021.12.03.374
    Cited : 4 times [Click to see citing articles]

  • IDEATIFICATIONFOR THE LEVEL ANTIBODES (IGG ANDIGM) OF TOXOPLASMA GONDIIIMMNOCOMPROMISEDPATIENTS IN KIRKUK CITY
    AbedullkaligAlwanmhemedQasim Ibrahim Khalaf
    J Cardiovasc. Dis. Res.. 2021; 12(3): 2925-2929
    » Abstract & References » doi: 10.31838/jcdr.2021.12.03.378
    Cited : 3 times [Click to see citing articles]