E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Article 


Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M..

Abstract
Background/Objectives: Pacemaker syndrome was mainly described as the sequel of atrioventricular (AV)
dyssynchrony. The role of interventricular (VV) dyssynchrony has not been studied yet. The aims of this study
were to noninvasively assess the hemodynamic effects of different ventricular pacing sites with and without
AV and VV dyssynchrony and to observe the patients for clinical symptoms of the pacemaker syndrome during
the AV sequential and ventricular-only pacing modes. Materials and Methods: Between March 2009 and
February 2010, 40 patients (28 men; mean age, 61 15 years) with biventricular (BiV) device were enrolled.
Mean systolic and diastolic blood pressures (BP) of 5 beats were measured 5 minutes after each mode change
using fingertip plethysmography. The patients were also observed for the occurrence of symptoms suggestive
of the pacemaker syndrome, including dyspnea, palpitations, dizziness, presyncope, and syncope. Results:
There was no difference in mean systolic BP among different ventricular-only pacing modes (all P = NS).
However, mean systolic BP was significantly higher in AV sequential biventricular pacing (DDD-BiV) compared
with ventricular-only pacing modes (all P<0.05). In addition, there was no difference in terms of pacemaker
syndrome-related symptoms following mode change from DDD-BiV to DDD-RV or DDD-LV (all P>0.05).
Conclusions: The present study showed that the non-AV sequential BiV and LV pacing may have no significant
benefit compared with RV pacing in terms of systolic blood pressure. However, there was marked hemodynamic
improvement following mode change to AV sequential BiV pacing. This study may have important implications
for pathogenesis of pacemaker syndrome.

Key words: Atrioventricular synchrony, interventricular dyssynchrony, pacemaker syndrome


 
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How to Cite this Article
Pubmed Style

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M.. Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome. J Cardiovasc. Dis. Res.. 2012; 3(3): 200-203. doi:10.4103/0975-3583.98892


Web Style

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M.. Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome. http://www.jcdronline.org/?mno=93260 [Access: January 16, 2022]. doi:10.4103/0975-3583.98892


AMA (American Medical Association) Style

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M.. Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome. J Cardiovasc. Dis. Res.. 2012; 3(3): 200-203. doi:10.4103/0975-3583.98892



Vancouver/ICMJE Style

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M.. Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome. J Cardiovasc. Dis. Res.. (2012), [cited January 16, 2022]; 3(3): 200-203. doi:10.4103/0975-3583.98892



Harvard Style

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M. (2012) Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome. J Cardiovasc. Dis. Res., 3 (3), 200-203. doi:10.4103/0975-3583.98892



Turabian Style

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M.. 2012. Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome. Journal of Cardiovascular Disease Research, 3 (3), 200-203. doi:10.4103/0975-3583.98892



Chicago Style

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M.. "Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome." Journal of Cardiovascular Disease Research 3 (2012), 200-203. doi:10.4103/0975-3583.98892



MLA (The Modern Language Association) Style

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M.. "Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome." Journal of Cardiovascular Disease Research 3.3 (2012), 200-203. Print. doi:10.4103/0975-3583.98892



APA (American Psychological Association) Style

Mollazadeh R., Mohimi L., Zeighami M., Fazelifar A., Haghjoo M. (2012) Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome. Journal of Cardiovascular Disease Research, 3 (3), 200-203. doi:10.4103/0975-3583.98892





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