E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Article 


Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff.

Abstract
Background: Aged garlic extract (AGE) and coenzyme Q10 (CoQ10) have been shown to affect multiple
cardiovascular risk factors. The current study evaluates the effect of AGE combined with CoQ10 on
inflammatory markers and progression of coronary atherosclerosis compared with placebo. Methods and
Results: In this placebo-controlled, double-blind, randomized trial, 65 intermediate risk firefighters (age
55 6 years) were treated with a placebo capsule or a capsule containing AGE and CoQ10 (AGE+CoQ10,
1200 and 120 mg, respectively) daily for 1 year. All participants underwent coronary artery calcium (CAC)
scanning and C-reactive protein (CRP) at baseline and at 12 months. At 1 year, mean CAC progression
was significantly lower in AGE+CoQ10 (32 6 vs. 58 8, P = 0.01) than placebo. Similarly, CRP were
significantly decreased in AGE+CoQ10 compared with placebo (-0.12 0.24 vs. 0.91 0.56 mg/L, P <
0.05). After adjustment for age, gender, conventional cardiac risk factors, and statin therapy, AGE+CoQ10
was associated with 3.99 fold (95% 1.312.2, P = 0.01) lack of CAC progression compared with the placebo.
Conclusion: AGE+CoQ10 are associated with beneficial effects on inflammatory markers and reduced
progression of coronary atherosclerosis.

Key words: Aged garlic extract, atherosclerosis, coenzyme Q10, inflammatory markers


 
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How to Cite this Article
Pubmed Style

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff. Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. J Cardiovasc. Dis. Res.. 2012; 3(3): 185-190. doi:10.4103/0975-3583.98883


Web Style

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff. Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. http://www.jcdronline.org/?mno=93257 [Access: January 16, 2022]. doi:10.4103/0975-3583.98883


AMA (American Medical Association) Style

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff. Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. J Cardiovasc. Dis. Res.. 2012; 3(3): 185-190. doi:10.4103/0975-3583.98883



Vancouver/ICMJE Style

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff. Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. J Cardiovasc. Dis. Res.. (2012), [cited January 16, 2022]; 3(3): 185-190. doi:10.4103/0975-3583.98883



Harvard Style

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff (2012) Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. J Cardiovasc. Dis. Res., 3 (3), 185-190. doi:10.4103/0975-3583.98883



Turabian Style

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff. 2012. Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. Journal of Cardiovascular Disease Research, 3 (3), 185-190. doi:10.4103/0975-3583.98883



Chicago Style

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff. "Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial." Journal of Cardiovascular Disease Research 3 (2012), 185-190. doi:10.4103/0975-3583.98883



MLA (The Modern Language Association) Style

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff. "Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial." Journal of Cardiovascular Disease Research 3.3 (2012), 185-190. Print. doi:10.4103/0975-3583.98883



APA (American Psychological Association) Style

Irfan Zeb, Naser Ahmadi, Khurram Nasir, Jigar Kadakia, Vahid Nabavi Larijani, Ferdinand Flores, Dong Li, Matthew J Budoff (2012) Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. Journal of Cardiovascular Disease Research, 3 (3), 185-190. doi:10.4103/0975-3583.98883





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