E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Article 


Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty.

Abstract
Background: The incidence of heart failure in diabetic subjects is high even in the absence of hypertension and coronary artery disease. Aims: The purpose of this study was to study the incidence of diastolic dysfunction in diabetic subjects and its relation to age, duration of diabetes mellitus (DM), Glycosylated hemoglobin (HbA1c) levels, obesity indices and diabetic microangiopathies. Settings and Design: This was a case control prospective study conducted at the teaching hospital during a one year period. Materials and Methods: A total of 127 subjects (case) with type 2 diabetes of more than five years duration were studied. Total 100 healthy subjects were included as the control group. Echocardiography was performed to assess left ventricular diastolic function. Results: Out of the total 127 subjects, 69 (54.33%) from the case group had diastolic dysfunction, and 11% amongst 100 in the control group population showed the diastolic dysfunction (P < 0.001). Patients with a longer duration of DM (of 11 to 15 years) had a higher prevalence of diastolic dysfunction (P < 0.02). Subjects with high waist circumference and high waist to hip ratio had statistically significant diastolic dysfunction with P = 0.001 and P = < 0.02 respectively. Subjects with HbA1c > 7.5% had a higher prevalence of diastolic dysfunction than subjects with HbA1c < 7.5% (P < 0.02). Diastolic dysfunction was present in majority of the subjects with autonomic neuropathy and retinopathy. Conclusions: Present study reveals high incidence of diastolic dysfunction in asymptomatic diabetic; subjects and, this finding was correlated with the duration of diabetes, HbAlc levels, obesity indices and diabetic microangiopathies. We conclude that early diagnosis and institution of treatment will reduce morbidity and improve the outcomes, and prevent future heart failure.

Key words: Diastolic dysfunction, diabetes mellitus, echocardiography, heart failure


 
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How to Cite this Article
Pubmed Style

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty. Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. J Cardiovasc. Dis. Res.. 2011; 2(4): 213-222. doi:10.4103/0975-3583.89805


Web Style

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty. Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. http://www.jcdronline.org/?mno=93195 [Access: January 16, 2022]. doi:10.4103/0975-3583.89805


AMA (American Medical Association) Style

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty. Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. J Cardiovasc. Dis. Res.. 2011; 2(4): 213-222. doi:10.4103/0975-3583.89805



Vancouver/ICMJE Style

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty. Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. J Cardiovasc. Dis. Res.. (2011), [cited January 16, 2022]; 2(4): 213-222. doi:10.4103/0975-3583.89805



Harvard Style

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty (2011) Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. J Cardiovasc. Dis. Res., 2 (4), 213-222. doi:10.4103/0975-3583.89805



Turabian Style

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty. 2011. Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. Journal of Cardiovascular Disease Research, 2 (4), 213-222. doi:10.4103/0975-3583.89805



Chicago Style

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty. "Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function." Journal of Cardiovascular Disease Research 2 (2011), 213-222. doi:10.4103/0975-3583.89805



MLA (The Modern Language Association) Style

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty. "Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function." Journal of Cardiovascular Disease Research 2.4 (2011), 213-222. Print. doi:10.4103/0975-3583.89805



APA (American Psychological Association) Style

Virendra C. Patil, Harsha V. Patil, Kuldeep B. Shah, Jay D. Vasani, Pruthvi Shetty (2011) Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. Journal of Cardiovascular Disease Research, 2 (4), 213-222. doi:10.4103/0975-3583.89805





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