E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Article 


Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease

Venkata Rao, Ravi Kiran.

Abstract
Background: Coronary artery disease (CAD) is the most common cause of sudden death, and death of men
and women over 20 years of age. The aim of the study was to know if there is any linear correlation between
oxidants and abnormal lipid profile parameters in CAD. Materials and Methods: The present study includes
42 known CAD cases (age = 4175 years) and 33 age- and sex-matched healthy controls. Malondialdehyde
(MDA), total cholesterol, high-density lipoprotein (HDL) cholesterol, and triacylglyceride were measured and
low-density lipoprotein (LDL) cholesterol was calculated in both cases and controls, respectively. Results: MDA
was significantly increased in cases than controls (P = 0.0000001). Total cholesterol was high in cases than
controls (P = 0.0000001). HDL cholesterol was significantly decreased in cases than controls (P = 0.0000001).
LDL cholesterol was high in cases than controls (P = 0.0000001). Triacylglyceride was high in cases than
controls (P = 0.0000001). Insignificant positive correlation were observed between MDA and total cholesterol
(r = 0.258), between MDA and LDL cholesterol (r = 0.199), and between MDA and HDL cholesterol (r = 0.134).
Negative correlation was observed between MDA and triacylglyceride (r = -0.314). Conclusion: Increased
oxidative stress and abnormal lipid profile were observed in CAD cases. Our study showed that statistically
significant linear relationship could not be established between increased oxidative stress and abnormal lipid
profile parameters, suggesting that increased oxidative stress and abnormal lipid profile are two independent
risk factors in the pathomechanism of atherogenesis.

Key words: Abnormal lipid profile, atheromatous plaques, coronary artery, coronary artery disease, myocardium, oxidants


 
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Pubmed Style

Venkata Rao, Ravi Kiran. Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease. J Cardiovasc. Dis. Res.. 2011; 2(1): 57-60. doi:10.4103/0975-3583.78598


Web Style

Venkata Rao, Ravi Kiran. Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease. http://www.jcdronline.org/?mno=93010 [Access: January 16, 2022]. doi:10.4103/0975-3583.78598


AMA (American Medical Association) Style

Venkata Rao, Ravi Kiran. Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease. J Cardiovasc. Dis. Res.. 2011; 2(1): 57-60. doi:10.4103/0975-3583.78598



Vancouver/ICMJE Style

Venkata Rao, Ravi Kiran. Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease. J Cardiovasc. Dis. Res.. (2011), [cited January 16, 2022]; 2(1): 57-60. doi:10.4103/0975-3583.78598



Harvard Style

Venkata Rao, Ravi Kiran (2011) Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease. J Cardiovasc. Dis. Res., 2 (1), 57-60. doi:10.4103/0975-3583.78598



Turabian Style

Venkata Rao, Ravi Kiran. 2011. Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease. Journal of Cardiovascular Disease Research, 2 (1), 57-60. doi:10.4103/0975-3583.78598



Chicago Style

Venkata Rao, Ravi Kiran. "Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease." Journal of Cardiovascular Disease Research 2 (2011), 57-60. doi:10.4103/0975-3583.78598



MLA (The Modern Language Association) Style

Venkata Rao, Ravi Kiran. "Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease." Journal of Cardiovascular Disease Research 2.1 (2011), 57-60. Print. doi:10.4103/0975-3583.78598



APA (American Psychological Association) Style

Venkata Rao, Ravi Kiran (2011) Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease. Journal of Cardiovascular Disease Research, 2 (1), 57-60. doi:10.4103/0975-3583.78598





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