E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research (Original Article) 


Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco.

Abstract
Background: Some clinical evidence revealed that statins, apart from lowering cholesterol levels, also have an
antihypertensive effect. Our aim was to evaluate the existence of a possible association of statin therapy with
blood pressure (BP) control in clinical practice. Materials and Methods: Patients attending a hypertension/
dyslipidemia clinic were prospectively evaluated. Those patients with a diagnosis of stage 1 hypertension
and hypercholesterolemia who consented to participate were included in the study, either in the statin group
(when taking a statin) or in the control group (when not taking a statin). Exclusion criteria included dementia,
pregnancy, or breastfeeding, and history or evidence of stage 2 hypertension. Detailed clinical information was
prospectively obtained from medical records. A total of 110 hypertensive patients were assigned to the study
(82 in the statin group and 28 in the control group). Results: Although there were no significant differences
(P > 0.05) in both groups concerning gender, body mass index, antihypertensive pharmacotherapy, and serum
levels of high-density lipoprotein cholesterol and triglycerides, a higher BP control was observed in the statin
group (P = 0.002). Significantly lower systolic BP (−6.7 mmHg, P = 0.020) and diastolic BP (−6.4 mmHg,
P = 0.002) levels were reported in the statin group. Serum levels of low-density lipoprotein were also significantly
lower in the statin group (P < 0.001). Conclusions: This observational study detected an association of statin
therapy with BP control in hypertensive hypercholesterolemic patients in clinical practice. These findings raise
the possibility that statin therapy may be useful for BP control in the studied population.

Key words: Antihypertensives, blood pressure, hypercholesterolemia, hypertension, Portugal, statins


 
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How to Cite this Article
Pubmed Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. . 2011; 2(1): 44-49. doi:10.4103/0975-3583.78596


Web Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. http://www.jcdronline.org//?mno=93005 [Access: March 18, 2020]. doi:10.4103/0975-3583.78596


AMA (American Medical Association) Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. . 2011; 2(1): 44-49. doi:10.4103/0975-3583.78596



Vancouver/ICMJE Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. . (2011), [cited March 18, 2020]; 2(1): 44-49. doi:10.4103/0975-3583.78596



Harvard Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco (2011) Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. , 2 (1), 44-49. doi:10.4103/0975-3583.78596



Turabian Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. 2011. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. Journal of Cardiovascular Disease Research, 2 (1), 44-49. doi:10.4103/0975-3583.78596



Chicago Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. "Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice." Journal of Cardiovascular Disease Research 2 (2011), 44-49. doi:10.4103/0975-3583.78596



MLA (The Modern Language Association) Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. "Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice." Journal of Cardiovascular Disease Research 2.1 (2011), 44-49. Print. doi:10.4103/0975-3583.78596



APA (American Psychological Association) Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco (2011) Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. Journal of Cardiovascular Disease Research, 2 (1), 44-49. doi:10.4103/0975-3583.78596





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