E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Article 


Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco.

Abstract
Background: Some clinical evidence revealed that statins, apart from lowering cholesterol levels, also have an
antihypertensive effect. Our aim was to evaluate the existence of a possible association of statin therapy with
blood pressure (BP) control in clinical practice. Materials and Methods: Patients attending a hypertension/
dyslipidemia clinic were prospectively evaluated. Those patients with a diagnosis of stage 1 hypertension
and hypercholesterolemia who consented to participate were included in the study, either in the statin group
(when taking a statin) or in the control group (when not taking a statin). Exclusion criteria included dementia,
pregnancy, or breastfeeding, and history or evidence of stage 2 hypertension. Detailed clinical information was
prospectively obtained from medical records. A total of 110 hypertensive patients were assigned to the study
(82 in the statin group and 28 in the control group). Results: Although there were no significant differences
(P > 0.05) in both groups concerning gender, body mass index, antihypertensive pharmacotherapy, and serum
levels of high-density lipoprotein cholesterol and triglycerides, a higher BP control was observed in the statin
group (P = 0.002). Significantly lower systolic BP (−6.7 mmHg, P = 0.020) and diastolic BP (−6.4 mmHg,
P = 0.002) levels were reported in the statin group. Serum levels of low-density lipoprotein were also significantly
lower in the statin group (P < 0.001). Conclusions: This observational study detected an association of statin
therapy with BP control in hypertensive hypercholesterolemic patients in clinical practice. These findings raise
the possibility that statin therapy may be useful for BP control in the studied population.

Key words: Antihypertensives, blood pressure, hypercholesterolemia, hypertension, Portugal, statins


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Manuel Morgado
Articles by Sandra Rolo
Articles by Ana Filipa Macedo
Articles by Miguel Castelo-Branco
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. J Cardiovasc. Dis. Res.. 2011; 2(1): 44-49. doi:10.4103/0975-3583.78596


Web Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. http://www.jcdronline.org/?mno=93005 [Access: January 16, 2022]. doi:10.4103/0975-3583.78596


AMA (American Medical Association) Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. J Cardiovasc. Dis. Res.. 2011; 2(1): 44-49. doi:10.4103/0975-3583.78596



Vancouver/ICMJE Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. J Cardiovasc. Dis. Res.. (2011), [cited January 16, 2022]; 2(1): 44-49. doi:10.4103/0975-3583.78596



Harvard Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco (2011) Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. J Cardiovasc. Dis. Res., 2 (1), 44-49. doi:10.4103/0975-3583.78596



Turabian Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. 2011. Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. Journal of Cardiovascular Disease Research, 2 (1), 44-49. doi:10.4103/0975-3583.78596



Chicago Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. "Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice." Journal of Cardiovascular Disease Research 2 (2011), 44-49. doi:10.4103/0975-3583.78596



MLA (The Modern Language Association) Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco. "Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice." Journal of Cardiovascular Disease Research 2.1 (2011), 44-49. Print. doi:10.4103/0975-3583.78596



APA (American Psychological Association) Style

Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco (2011) Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice. Journal of Cardiovascular Disease Research, 2 (1), 44-49. doi:10.4103/0975-3583.78596





Most Viewed Articles
  • Effects of right ventricular septal versus apical pacing on plasma natriuretic peptide levels
    nikoo M.H, ghaedian m. m., kafi M., fakhrpour A., Jorat M. V., Pakfetrat M., Ostovan M., Zahra Emkanjoo
    J Cardiovasc. Dis. Res.. 2011; 2(2): 104-109
    » Abstract » doi: 10.4103/0975-3583.83036

  • Massive pericardial effusion as the only manifestation of primary hypothyroidism
    Radheshyam Purkait , Anand Prasad , Ramchandra Bhadra , Arindam Basu
    J Cardiovasc. Dis. Res.. 2013; 4(4): 248-250
    » Abstract » doi: 10.1016/j.jcdr.2014.01.001

  • Impact of light exercises in selective cognitive response andhandballshooting accuracy performance in Mesopotamia handball players
    Ahuda Naji Zaidan, Qusay Mohammed Hamdan, Mohammed Kadhim Saleh, Samer Saadoun Abd El , Rida
    J Cardiovasc. Dis. Res.. 2021; 12(2): 141-145
    » Abstract » doi: 10.31838/jcdr.2021.12.02.18

  • Reduced nitrate level in individuals with hypertension and diabetes
    Shiekh Gazalla Ayub, Taha Ayub, Saquib Naveed Khan, Rubiya Dar, Khurshid Iqbal Andrabi
    J Cardiovasc. Dis. Res.. 2011; 2(3): 172-176
    » Abstract » doi: 10.4103/0975-3583.85264

  • Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians
    Mithun Das, Susil Pal, Arnab Ghosh
    J Cardiovasc. Dis. Res.. 2010; 1(2): 86-91
    » Abstract » doi: 10.4103/0975-3583.64442

  • Most Downloaded
  • Assessment of the Knowledge and Attitude of Male Students towards Smoking Based on Health Belief Model
    Rafat Rezapour-Nasrabad, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Khatereh Rostami, Amin Kiani, Afsaneh Ghasemi
    J Cardiovasc. Dis. Res.. 2020; 11(4): 116-121
    » Abstract » doi: 10.31838/jcdr.2020.11.04.20

  • Diabetic Retinopathy, The Automated of Detection of Retinal Fundus Images with Probabilistic Neural Networks (PNN)
    Elvina Amanda, Marischa Elveny, Rahmad Syah
    J Cardiovasc. Dis. Res.. 2020; 11(4): 302-306
    » Abstract » doi: 10.31838/jcdr.2020.11.04.54

  • Investigation of the Relationship between Social Support and Adherence to Treatment among Elderly Individuals with Type II Diabetes Mellitus
    Afsaneh Ghasemi, Rafat Rezapour-Nasrabad, Leila Nikrouz, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Zahra Khiali
    J Cardiovasc. Dis. Res.. 2020; 11(4): 122-129
    » Abstract » doi: 10.31838/jcdr.2020.11.04.21

  • Evaluation of the RV function in ASD patients pre and post transcatheter occlusion by speckle tracking
    Ghazi Farhan Haji, Venus Abdulwahid Alwan, Sa`ad Hashim Mohammed
    J Cardiovasc. Dis. Res.. 2020; 11(1): 24-30
    » Abstract » doi: 10.31838/jcdr.2020.11.01.07

  • Preclinical Study of Derivative of 3-Oxypiridone in Experimental Pre-Eclampsia
    Alesya V. Yurakova, Sofya Y.Skachilova, Lyudmila M.Danilenko, Indira S. Kochkarova, Natalia V.Ekimova, Anastasia V. Gureeva, Il'ya S. Rozhkov, Adelaida V. Polyanskaya
    J Cardiovasc. Dis. Res.. 2020; 11(4): 66-70
    » Abstract » doi: 10.31838/jcdr.2020.11.04.11

  • Most Cited Articles
  • Alterations in oropharyngeal airway volume and dimensions following treatment with mandibular anterior repositioning in class II malocclusion
    Dr Wagisha Barbi, Dr. Jasmine Nindra, Dr. Pranav Manek, Dr. Partho Shankar Chakraborty, Dr. Priyadarshini Rangari
    J Cardiovasc. Dis. Res.. 2021; 12(6): 603-607
    » Abstract & References » doi: 10.31838/jcdr.2021.12.06.81
    Cited : 6 times [Click to see citing articles]

  • The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children
    Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra
    J Cardiovasc. Dis. Res.. 2021; 12(6): 484-489
    » Abstract & References » doi: 10.31838/jcdr.2021.12.06.65
    Cited : 5 times [Click to see citing articles]

  • To Determine the Influence of Body Mass Index on Blood Pressure in People with Hypertension
    Dr. Rajesh Kumar Pandey, Asha Kumari, Dr.S.N.Sachit, Dr.V.K.Mishra
    J Cardiovasc. Dis. Res.. 2021; 12(4): 1634-1643
    » Abstract & References » doi: 10.31838/jcdr.2021.12.03.172
    Cited : 4 times [Click to see citing articles]

  • IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA
    Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur
    J Cardiovasc. Dis. Res.. 2021; 12(3): 2882-2895
    » Abstract & References » doi: 10.31838/jcdr.2021.12.03.374
    Cited : 4 times [Click to see citing articles]

  • IDEATIFICATIONFOR THE LEVEL ANTIBODES (IGG ANDIGM) OF TOXOPLASMA GONDIIIMMNOCOMPROMISEDPATIENTS IN KIRKUK CITY
    AbedullkaligAlwanmhemedQasim Ibrahim Khalaf
    J Cardiovasc. Dis. Res.. 2021; 12(3): 2925-2929
    » Abstract & References » doi: 10.31838/jcdr.2021.12.03.378
    Cited : 3 times [Click to see citing articles]