E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Article 


Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance

Hamdy Sliem, Gamela Nasr.

Abstract
Introduction: Several studies have shown that ventricular dysfunction is increased in individuals with diabetes.
Insulin resistance (IR) may precede type 2 diabetes, and is a pathogenic factor for it. Furthermore, IR has been
shown to be an independent predictor of cardiovascular disease in diabetes. Given that glucose intolerance and
IR precede the development of overt diabetes, these factors would be associated with abnormal myocardial
performance. Aim of the Work: To evaluate the state of left ventricular structure and function in prediabetic
adults in relation with IR. Patients and Methods: A case–control study was performed. One hundred and
twenty-one consecutive adults with prediabetes were enrolled for the study. Forty-two of the adults had IR
(group A) and 79 had insulin sensitivity (group B). Forty-three healthy (with normal blood glucose) adults
matched for age and gender were considered as a control group. All groups were subjected to full medical
history and clinical examination and biochemical and echocardiographic studies. Results: There were no
statistically significant differences between the insulin-sensitive prediabetic group and the control group in all
parameters of left ventricular structure and systolic and diastolic functions. Significant differences were observed
between group A and control group in the parameters of left ventricular diastolic function (both isovolumetric
relaxation time and E/A ratio). Regarding correlation between the parameters of diastolic function and different
variables of IR prediabetic group, there was a statistically significant coefficient correlation with HOMA IR,
waist circumference and triglycerides. No correlation was observed with fasting glucose, Hb A1c, body mass
index, blood pressure (BP) and total lipids. Conclusion: In prediabetic adults, IR is associated with impaired
left ventricular diastolic function, and this association appears to be independent of BP, ventricular geometry,
glucose tolerance status, total plasma lipids and obesity.

Key words: Insulin resistance, prediabetes, ventricular function


 
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Pubmed Style

Hamdy Sliem, Gamela Nasr. Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance. J Cardiovasc. Dis. Res.. 2011; 2(1): 23-28. doi:10.4103/0975-3583.78583


Web Style

Hamdy Sliem, Gamela Nasr. Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance. http://www.jcdronline.org/?mno=93001 [Access: January 16, 2022]. doi:10.4103/0975-3583.78583


AMA (American Medical Association) Style

Hamdy Sliem, Gamela Nasr. Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance. J Cardiovasc. Dis. Res.. 2011; 2(1): 23-28. doi:10.4103/0975-3583.78583



Vancouver/ICMJE Style

Hamdy Sliem, Gamela Nasr. Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance. J Cardiovasc. Dis. Res.. (2011), [cited January 16, 2022]; 2(1): 23-28. doi:10.4103/0975-3583.78583



Harvard Style

Hamdy Sliem, Gamela Nasr (2011) Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance. J Cardiovasc. Dis. Res., 2 (1), 23-28. doi:10.4103/0975-3583.78583



Turabian Style

Hamdy Sliem, Gamela Nasr. 2011. Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance. Journal of Cardiovascular Disease Research, 2 (1), 23-28. doi:10.4103/0975-3583.78583



Chicago Style

Hamdy Sliem, Gamela Nasr. "Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance." Journal of Cardiovascular Disease Research 2 (2011), 23-28. doi:10.4103/0975-3583.78583



MLA (The Modern Language Association) Style

Hamdy Sliem, Gamela Nasr. "Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance." Journal of Cardiovascular Disease Research 2.1 (2011), 23-28. Print. doi:10.4103/0975-3583.78583



APA (American Psychological Association) Style

Hamdy Sliem, Gamela Nasr (2011) Left ventricular structure and function in prediabetic adults:Relationship with insulin resistance. Journal of Cardiovascular Disease Research, 2 (1), 23-28. doi:10.4103/0975-3583.78583





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