E-ISSN 0976-2833 | ISSN 0975-3583
 

Review Article 


Mesenchymal stromal cells for cardiovascular disease

Ian B. Copland.

Abstract
The fields of regenerative medicine and cellular therapy have been the subject of tremendous hype and hope.
In particular, the perceived usage of somatic cells like mesenchymal stromal cells (MSCs) has captured the
imagination of many. MSCs are a rare population of cells found in multiple regions within the body that can
be readily expanded ex vivo and utilized clinically. Originally, it was hypothesized that transplantation of
MSCs to sites of injury would lead to de novo tissue-specific differentiation and thereby replace damaged
tissue. Now, it is generally agreed that MSC home to sites of injury and direct positive remodeling via the
secretion of paracrine factors. Consequently, their clinical utilization has largely revolved around their abilities
to promote neovascularization for ischemic disorders and modulate overly exuberant inflammatory responses
for autoimmune and alloimmune conditions. One of the major issues surrounding the development of somatic
cell therapies like MSCs is that despite evoking a positive response, long-term engraftment and persistence of
these cells is rare. Consequently, very large cell doses need be administered for raising production, delivery,
and efficacy issues. In this review, we will outline the field of MSC in the context of ischemia and discuss
causes for their lack of persistence. In addition, some of the methodologies be used to enhance their therapeutic
potential will be highlighted.

Key words: Ischemia paracrine, mesenchymal stromal cells


 
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Pubmed Style

Ian B. Copland. Mesenchymal stromal cells for cardiovascular disease. J Cardiovasc. Dis. Res.. 2011; 2(1): 3-13. doi:10.4103/0975-3583.78581


Web Style

Ian B. Copland. Mesenchymal stromal cells for cardiovascular disease. http://www.jcdronline.org/?mno=92999 [Access: January 16, 2022]. doi:10.4103/0975-3583.78581


AMA (American Medical Association) Style

Ian B. Copland. Mesenchymal stromal cells for cardiovascular disease. J Cardiovasc. Dis. Res.. 2011; 2(1): 3-13. doi:10.4103/0975-3583.78581



Vancouver/ICMJE Style

Ian B. Copland. Mesenchymal stromal cells for cardiovascular disease. J Cardiovasc. Dis. Res.. (2011), [cited January 16, 2022]; 2(1): 3-13. doi:10.4103/0975-3583.78581



Harvard Style

Ian B. Copland (2011) Mesenchymal stromal cells for cardiovascular disease. J Cardiovasc. Dis. Res., 2 (1), 3-13. doi:10.4103/0975-3583.78581



Turabian Style

Ian B. Copland. 2011. Mesenchymal stromal cells for cardiovascular disease. Journal of Cardiovascular Disease Research, 2 (1), 3-13. doi:10.4103/0975-3583.78581



Chicago Style

Ian B. Copland. "Mesenchymal stromal cells for cardiovascular disease." Journal of Cardiovascular Disease Research 2 (2011), 3-13. doi:10.4103/0975-3583.78581



MLA (The Modern Language Association) Style

Ian B. Copland. "Mesenchymal stromal cells for cardiovascular disease." Journal of Cardiovascular Disease Research 2.1 (2011), 3-13. Print. doi:10.4103/0975-3583.78581



APA (American Psychological Association) Style

Ian B. Copland (2011) Mesenchymal stromal cells for cardiovascular disease. Journal of Cardiovascular Disease Research, 2 (1), 3-13. doi:10.4103/0975-3583.78581





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