E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra.

Cited by (5)

Abstract
Abstract
Aim: To study the effect of vitamin D supplementation in severity and control of
bronchial asthma in children in Bihar region
Methods: A cross-sectional, prospective study was conducted in the Department of
pediatrics, Vardhman institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India for
1 year, after taking the approval of the protocol review committee and institutional
ethics committee. 53 asthmatic patients and 53 healthy controls were included in this
study. The level of serum vitamin D in both groups was measured by radioimmunoassay
( RIA)
method at the reference lab and was categorized as sufficient (> 30 ng/ml), insufficient
(20 to 30 ng/ml), or deficient (< 20 ng/ml). The severity of asthma was also stratified
according to the asthma guideline into four grades of intermittent or mild, moderate,
severe persistent.
Results: Regarding rate of admission, 13.2% of patients were hospitalized once, 9.4%
of patients were hospitalized twice, and 1.9% of them were also hospitalized three
times. In the patients group and regarding the severity of asthma, 11.3% were classified
as mild asthma, 45.3% as moderate asthma, and 43.4% as severe asthma. Also regarding
control status of asthma, the disease was controlled in 18.9 %, partially controlled in
34.0 %, and uncontrolled in 47.2 %. According to the level of disease attack risk, 5 of
31 children aged less than 5 years (16.1%) classified as high-risk, while 7 of 22 children
older than 5 years (31.8%) classified as high risk. Assessing the serum level of vitamin
D showed that the asthmatic children had significantly lower level of vitamin D
Journal of Cardiovascular Disease Research

ISSN: 0975-3583, 0976-2833 VOL 12, ISSUE 06, 2021
485
compared to normal cases (14.53 8.10 ng.ml versus 22.45 13.46 ng/ml, p < 0.001).
Also, in the groups with and without asthma, the prevalence of vitamin D deficiency
was 73.6 and 49.1%, and the prevalence of vitamin D insufficiency was 18.9 and 18.9
%, while normal vitamin D level was revealed in 7.5 and 32.1%, respectively with a
significant difference (p = 0.005). In this regard, mean serum level of vitamin D in the
patients with mild asthma was 12.85 7.06 ng/ml, in the group with moderate asthma
was 16.98 8.63 ng/ml, in the patients with severe asthma was 12.42 7.52 ng/ml,
and in those with persistent asthma was 12.01 5.00 ng/ml (p = 0.25).
Conclusion: Vitamin D deficiency and insufficiency is a common finding among asthmatic
children that may be associated by the physiological mechanism of this phenomenon.
In fact, it seems that the use of supplement vitamin D can prevent progression of
childhood asthma.

Key words: Vitamin D, children, asthma


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Dr. Sushant Kumar
Articles by Dr Sanjeev Kumar
Articles by Dr. Vinod Kumar Mishra
on Google
on Google Scholar


REFERENCES
1.Valko M, Leibfritz D, Moncol J, Cronin M, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39:44-84.

http://dx.doi.org/10.1016/j.biocel.2006.07.001

[Pubmed]   


2.Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol 1997; 82:291-5.

[
Pubmed]   


3.Jayaprakash GK, Rao LJ. Phenolic constituents from lichen Parmontrema stuppeum (Nyl.) Hale and their antioxidant activity. Z Naturforsch 2000; 55:1018-22.


4.Corrado B, Marco T, Colucci R, Fornai M, Antonioli L, Ghisu N, Tacca MD. Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti inflammatory therapy. Pharm Res 2009; 59:90-100.

http://dx.doi.org/10.1016/j.phrs.2008.11.004

[
Pubmed]   


5.Eliana R, Ricardo T, Jose C, Galduroz F, Giuseppina N. Plants with possible anxiolytic and/or hypnotic effects indicated by three brazilian cultures - indians, afrobrazilians, and river-dwellers. Studies in Natural Products Chemistry 2008; 35:549-95.

http://dx.doi.org/10.1016/S1572-5995(08)80014-2


6.Adnaik RS, Pai PT, Sapakal VD, Naikwade NS, Magdum CS. Anxiolytic activity of Vitex negundo Linn in experimental models of anxiety in mice. Int J Green Pharm 2009; 3:243-47.

http://dx.doi.org/10.4103/0973-8258.56284


7.Robin D. Nymphaea odorata: White pond lily. Medical Herbalism 2001; 11:6-7.


8.Vergeera LH, Vander VG. Phenolic content of daylight-exposed and shaded floating leaves of water lilies (Nymphaeaceae) in relation to infection by fungi. Oecologia 1997; 112:481-4.

http://dx.doi.org/10.1007/s004420050335


9.Duke JA. Duke's Handbook of Medicinal Plants of the Bible. CRC Press, Boca Raton, FL, USA, pp 302-305, 2008.

http://dx.doi.org/10.1201/9781420043174


10.Khan N, Sultana S. Anticarcinogenic effect of Nymphaea alba against oxidative damage and hyperproliferative response and renal carcinogenis in Wistar rats. Mol Cell Biochem 2005; 271:1-11.

http://dx.doi.org/10.1007/s11010-005-2258-2

[
Pubmed]   


11.Naghma K, Sarwat S. Inhibition of potassium bromate-induced renal oxidative stress and hyperproliferative response by Nymphaea alba in Wistar rats. J Enzyme Inhib Med Chem 2005; 20:275-83.

http://dx.doi.org/10.1080/14756360400028119

[
Pubmed]   


12.Bagul M, Srinivasa H, Padh H, Rajani M. A rapid densitometric method for simultaneous quantification of gallic acid and ellagic acid in herbal raw materials using HPTLC. J Sep Sci 2005; 28:581-4.

http://dx.doi.org/10.1002/jssc.200301695

[
Pubmed]   


13.Madhusudhan N, Lakshmi T, Gowtham KS, Ramakrishanan, Konda VGR, Roy A, Geetha RV. Invitro antioxidant and free radical scavenging activity of aqueous and ethanolic flower extract of Nymphaea alba. Int J Drug Dev Res 2011; 3:23-6.


14.Evans WC. Trease and Evans Pharmacognosy. 14th edition, WB Sauders, London, UK, pp 56-58, 1996.


15.Sawadogo WR, Boly R, Lompo M, Some N, Lamien CE, Guissou IP, Nacoulma OG. Anti-inflammatory, analgesic and antipyretic activities of Dicliptera verticillata. Int J Pharmacol 2006; 2:435-8.

http://dx.doi.org/10.3923/ijp.2006.435.438


16.Wibool R, Sae WC, Reanmongkol W, Wongnawaa M. Antinociceptive activity of the methanolic extract of Kaempferia galangalLinn. in experimental animals. J Ethnopharmacol 2008; 118: 225-30.

http://dx.doi.org/10.1016/j.jep.2008.04.002

[
Pubmed]   


17.Koduru S, Jimoh FO, Grierson DS, Afolayan AJ. Antioxidant activity of twosteroid alkaloids extracted from Solanum aculeastrum. J Pharmacol Toxicol 2007; 2:160-7.

http://dx.doi.org/10.3923/jpt.2007.160.167


18.Singelton VR, Orthifer R, Lamuela-Raventos RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 1999; 299:152-78.

http://dx.doi.org/10.1016/S0076-6879(99)99017-1


19.Braca A, Tommasi ND, Bari LD, Pizza C, Politi M, Morelli I. Antioxidant principles from Bauhinia terapotensis. J Nat Prod 2001; 64:892-5.

http://dx.doi.org/10.1021/np0100845

[
Pubmed]   


20.Govindarajan R, Rastogi S, Vijayakumar M, Shirwaikar A, Rawat AK, Mehrotra S, Pushpangadan P. Studies on antioxidant activities of Desmodium gangeticum. Biol Pharm Bull 2003; 26:1424-425.

http://dx.doi.org/10.1248/bpb.26.1424

[
Pubmed]   


21.Nishikimi M, Appaji N, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazinemethosulphate and molecular oxygen. Biochem Biophys Res Commun 1972; 46:849-54.

http://dx.doi.org/10.1016/S0006-291X(72)80218-3

[
Pubmed]   


22.Svilaas A, Sakhi AK, Andersen LF, Svilaas T, Strom EC, Jacobs DR, Ose L, Blomhoff R. Intakes of antioxidants in coffee, wine and vegetables are correlated with plasma carotenoids in humans. J Nutr 2004; 134:562-7.

[
Pubmed]   


23.Parke DV, Sapota A. Chemical toxicity and reactive species. Int J Occup Med Environ Health 1996; 9:119-23.


24.Rahman MAA, Moon SS. Antioxidant polyphenol glycosides from the Plant Draba nemorosa. Bull Korean Chem Soc 2007; 28:827-31.

http://dx.doi.org/10.5012/bkcs.2007.28.5.827


25.Kok CJ, Hof CHJ, Lenssen JPM, van der Velde G.The influence of pH on concentrations of protein and phenolics and resource quality of decomposing floating leaf material of Nymphaea alba L. (Nymphaeaceae) for the detritivore Asellus aquaticus (L.). Oecologia 1992; 91:229-34.

http://dx.doi.org/10.1007/BF00317788


26.Hagerman AE, Riedl KM, Jones GA, Sovik KN, Ritchard NT, Hartzfeld PW, Riechel TL. High molecular weight plant polyphenolics (tannins) as biological antioxidants. J Agric Food Chem 1998; 46:1887-92.

http://dx.doi.org/10.1021/jf970975b


27.Eldahshan OA, Ayoub NA, Singab ANB, Al-Azizi MM. Potential superoxide anion radical scavenging activity of Doum Palm (Hyphaene thebaica L.) leaves extract. Rec Nat Prod 2008; 2:83-93.


28.Kaur P, Arora S. Superoxide anion radical scavenging activity of Cassia siamea and Cassia javanica. Med Chem Res 2011; 20: 9-15.

http://dx.doi.org/10.1007/s00044-009-9274-9


This Article Cited By the following articles


2019; (): 135.

1
 
Characterization of the bioactive constituents of Nymphaea alba rhizomes and evaluation of anti-biofilm as well as antioxidant and cytotoxic properties
J. Med. Plants Res. 2016; 10(26): 390.

2
 
Scientific evaluation of medicinal plants used for the treatment of abnormal uterine bleeding by Avicenna
Archives of Gynecology and Obstetrics 2015; 292(1): 21-35.

3
 
Anti-inflammatory and anti-oxidative effects of herbal preparation EM 1201 in adjuvant arthritic rats
Medicina 2015; 51(6): 368-377.

4
 
An Evidence-based Review on Medicinal Plants used for the Treatment of Peptic Ulcer in Traditional Iranian Medicine
International Journal of Pharmacology 2013; 9(2): 108-124.

5
 
How to Cite this Article
Pubmed Style

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra. The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children. J Cardiovasc. Dis. Res.. 2021; 12(6): 484-489. doi:10.31838/jcdr.2021.12.06.65


Web Style

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra. The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children. http://www.jcdronline.org/?mno=23508 [Access: January 16, 2022]. doi:10.31838/jcdr.2021.12.06.65


AMA (American Medical Association) Style

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra. The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children. J Cardiovasc. Dis. Res.. 2021; 12(6): 484-489. doi:10.31838/jcdr.2021.12.06.65



Vancouver/ICMJE Style

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra. The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children. J Cardiovasc. Dis. Res.. (2021), [cited January 16, 2022]; 12(6): 484-489. doi:10.31838/jcdr.2021.12.06.65



Harvard Style

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra (2021) The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children. J Cardiovasc. Dis. Res., 12 (6), 484-489. doi:10.31838/jcdr.2021.12.06.65



Turabian Style

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra. 2021. The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children. Journal of Cardiovascular Disease Research, 12 (6), 484-489. doi:10.31838/jcdr.2021.12.06.65



Chicago Style

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra. "The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children." Journal of Cardiovascular Disease Research 12 (2021), 484-489. doi:10.31838/jcdr.2021.12.06.65



MLA (The Modern Language Association) Style

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra. "The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children." Journal of Cardiovascular Disease Research 12.6 (2021), 484-489. Print. doi:10.31838/jcdr.2021.12.06.65



APA (American Psychological Association) Style

Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra (2021) The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children. Journal of Cardiovascular Disease Research, 12 (6), 484-489. doi:10.31838/jcdr.2021.12.06.65





Most Viewed Articles
  • Effects of right ventricular septal versus apical pacing on plasma natriuretic peptide levels
    nikoo M.H, ghaedian m. m., kafi M., fakhrpour A., Jorat M. V., Pakfetrat M., Ostovan M., Zahra Emkanjoo
    J Cardiovasc. Dis. Res.. 2011; 2(2): 104-109
    » Abstract » doi: 10.4103/0975-3583.83036

  • Massive pericardial effusion as the only manifestation of primary hypothyroidism
    Radheshyam Purkait , Anand Prasad , Ramchandra Bhadra , Arindam Basu
    J Cardiovasc. Dis. Res.. 2013; 4(4): 248-250
    » Abstract » doi: 10.1016/j.jcdr.2014.01.001

  • Impact of light exercises in selective cognitive response andhandballshooting accuracy performance in Mesopotamia handball players
    Ahuda Naji Zaidan, Qusay Mohammed Hamdan, Mohammed Kadhim Saleh, Samer Saadoun Abd El , Rida
    J Cardiovasc. Dis. Res.. 2021; 12(2): 141-145
    » Abstract » doi: 10.31838/jcdr.2021.12.02.18

  • Reduced nitrate level in individuals with hypertension and diabetes
    Shiekh Gazalla Ayub, Taha Ayub, Saquib Naveed Khan, Rubiya Dar, Khurshid Iqbal Andrabi
    J Cardiovasc. Dis. Res.. 2011; 2(3): 172-176
    » Abstract » doi: 10.4103/0975-3583.85264

  • Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians
    Mithun Das, Susil Pal, Arnab Ghosh
    J Cardiovasc. Dis. Res.. 2010; 1(2): 86-91
    » Abstract » doi: 10.4103/0975-3583.64442

  • Most Downloaded
  • Assessment of the Knowledge and Attitude of Male Students towards Smoking Based on Health Belief Model
    Rafat Rezapour-Nasrabad, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Khatereh Rostami, Amin Kiani, Afsaneh Ghasemi
    J Cardiovasc. Dis. Res.. 2020; 11(4): 116-121
    » Abstract » doi: 10.31838/jcdr.2020.11.04.20

  • Diabetic Retinopathy, The Automated of Detection of Retinal Fundus Images with Probabilistic Neural Networks (PNN)
    Elvina Amanda, Marischa Elveny, Rahmad Syah
    J Cardiovasc. Dis. Res.. 2020; 11(4): 302-306
    » Abstract » doi: 10.31838/jcdr.2020.11.04.54

  • Investigation of the Relationship between Social Support and Adherence to Treatment among Elderly Individuals with Type II Diabetes Mellitus
    Afsaneh Ghasemi, Rafat Rezapour-Nasrabad, Leila Nikrouz, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Zahra Khiali
    J Cardiovasc. Dis. Res.. 2020; 11(4): 122-129
    » Abstract » doi: 10.31838/jcdr.2020.11.04.21

  • Evaluation of the RV function in ASD patients pre and post transcatheter occlusion by speckle tracking
    Ghazi Farhan Haji, Venus Abdulwahid Alwan, Sa`ad Hashim Mohammed
    J Cardiovasc. Dis. Res.. 2020; 11(1): 24-30
    » Abstract » doi: 10.31838/jcdr.2020.11.01.07

  • Preclinical Study of Derivative of 3-Oxypiridone in Experimental Pre-Eclampsia
    Alesya V. Yurakova, Sofya Y.Skachilova, Lyudmila M.Danilenko, Indira S. Kochkarova, Natalia V.Ekimova, Anastasia V. Gureeva, Il'ya S. Rozhkov, Adelaida V. Polyanskaya
    J Cardiovasc. Dis. Res.. 2020; 11(4): 66-70
    » Abstract » doi: 10.31838/jcdr.2020.11.04.11

  • Most Cited Articles
  • Alterations in oropharyngeal airway volume and dimensions following treatment with mandibular anterior repositioning in class II malocclusion
    Dr Wagisha Barbi, Dr. Jasmine Nindra, Dr. Pranav Manek, Dr. Partho Shankar Chakraborty, Dr. Priyadarshini Rangari
    J Cardiovasc. Dis. Res.. 2021; 12(6): 603-607
    » Abstract & References » doi: 10.31838/jcdr.2021.12.06.81
    Cited : 6 times [Click to see citing articles]

  • The Comparative Assessment of the Effect of Vitamin D Supplementation on the Severity and Control of Bronchial Asthma in Children
    Dr. Sushant Kumar, Dr Sanjeev Kumar, Dr. Vinod Kumar Mishra
    J Cardiovasc. Dis. Res.. 2021; 12(6): 484-489
    » Abstract & References » doi: 10.31838/jcdr.2021.12.06.65
    Cited : 5 times [Click to see citing articles]

  • To Determine the Influence of Body Mass Index on Blood Pressure in People with Hypertension
    Dr. Rajesh Kumar Pandey, Asha Kumari, Dr.S.N.Sachit, Dr.V.K.Mishra
    J Cardiovasc. Dis. Res.. 2021; 12(4): 1634-1643
    » Abstract & References » doi: 10.31838/jcdr.2021.12.03.172
    Cited : 4 times [Click to see citing articles]

  • IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA
    Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur
    J Cardiovasc. Dis. Res.. 2021; 12(3): 2882-2895
    » Abstract & References » doi: 10.31838/jcdr.2021.12.03.374
    Cited : 4 times [Click to see citing articles]

  • IDEATIFICATIONFOR THE LEVEL ANTIBODES (IGG ANDIGM) OF TOXOPLASMA GONDIIIMMNOCOMPROMISEDPATIENTS IN KIRKUK CITY
    AbedullkaligAlwanmhemedQasim Ibrahim Khalaf
    J Cardiovasc. Dis. Res.. 2021; 12(3): 2925-2929
    » Abstract & References » doi: 10.31838/jcdr.2021.12.03.378
    Cited : 3 times [Click to see citing articles]