E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research (Original Article) 


Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa.

Abstract
Background and Objective: Ischemic heart disease (IHD) is one of the commonest reasons for morbidity and mortality universally. The principal etiopathology of IHD is coronary atherosclerosis. Serum uric acid (SUA), is found to be associated with IHD in several meta-analyses, independent of other risk factors. Hepatic acute phase reactant ''C-reactive protein (CRP)'' has a recognized contribution to vascular inflammation. Up till now, no sufficient data is yet available to show the correlation of both UA and HSCRP to each other and with IHD in our country. Therefore, this study was conducted to evaluate the causal-effect of SUA, and CRP and their diagnostic correlation in admitted patients with IHD.

Material and Methods: This was a case-control study, including 260 participants (160 patients with IHD and 100 healthy control). Blood samples were drawn from all participants within 24 hours of admission. Biochemical analyses included: fasting/random glucose, total lipid profile, creatinine, estimated GFR, SUA and HSCRP tests were completed for all participants were measured. According to their SUA levels participants divided into normourecemic and hyperuricemic groups (≤6.5 and > 6.5mg/dl sequentially). Likewise, serum levels of HSCRP into (< 3.5 mg/L and >3.5mg/L). A comparison of biochemical findings between IHD and controls were performed. SPSS-25 (IBM-USA) was applied for the statistical examination. Estimations of ORs, as well as 95% confidence intervals, where stated. P-values < 0.05 were allocated as significant. ROC-curve examination was analyzed to determine accuracy, specificity, sensitivity for both SUA and HSCRP mutually.

Results: The overall prevalence of hyperuricemia was 29% among all participants and was equivalent in both sexes, while HSCRP tertiles were higher significantly in males (p-0.003). Biochemical assays of SUA, HSCRP and lipid profile being higher in IHD patients significantly. There was a trend to have a higher risk of IHD occurrence in those with higher SUA and HSCRP mutually but not reach a statistical significance. After ROC-curve was analyzed, significant higher predictability of HSCRP vis SUA for diagnosing subjects with IHD as an outcome was reached. There was no strong association between the SUA and HSCRP. Still, the levels of HSCRP may have an association with increased SUA levels, but not reach statistical significance.

Conclusions: Serum levels of both UA and HSCRP increased significantly in patients with IHD. Higher levels of HSCRP could have an association with higher levels of SUA. Further studies are mandatory to complete our understanding pathophysiology of IHD and AS process.

Key words: HSCRP, Ischemic heart diseases, hyperuricemia


 
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Pubmed Style

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa. Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases. . 2020; 11(2): 25-31. doi:10.31838/jcdr.2020.11.02.06


Web Style

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa. Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases. http://www.jcdronline.org//?mno=109333 [Access: May 22, 2020]. doi:10.31838/jcdr.2020.11.02.06


AMA (American Medical Association) Style

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa. Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases. . 2020; 11(2): 25-31. doi:10.31838/jcdr.2020.11.02.06



Vancouver/ICMJE Style

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa. Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases. . (2020), [cited May 22, 2020]; 11(2): 25-31. doi:10.31838/jcdr.2020.11.02.06



Harvard Style

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa (2020) Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases. , 11 (2), 25-31. doi:10.31838/jcdr.2020.11.02.06



Turabian Style

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa. 2020. Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases. Journal of Cardiovascular Disease Research, 11 (2), 25-31. doi:10.31838/jcdr.2020.11.02.06



Chicago Style

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa. "Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases." Journal of Cardiovascular Disease Research 11 (2020), 25-31. doi:10.31838/jcdr.2020.11.02.06



MLA (The Modern Language Association) Style

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa. "Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases." Journal of Cardiovascular Disease Research 11.2 (2020), 25-31. Print. doi:10.31838/jcdr.2020.11.02.06



APA (American Psychological Association) Style

Hajir Karim Abdul Husseein, Fouad Sharif Dleikh, Ameera Jasim Al-Aaraji, Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar Mousa (2020) Biochemical Causal-Effect of Circulatory Uric Acid, and HSCRP and their Diagnostic Correlation in Admitted Patients with Ischemic Heart Diseases. Journal of Cardiovascular Disease Research, 11 (2), 25-31. doi:10.31838/jcdr.2020.11.02.06





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